Chromatin reassembly factors are involved in transcriptional interference promoting HIV latency.

ABSTRACT: The establishment of a stable reservoir of latently infected cells allows HIV to persist in the host. Usually, HIV infection of T cells results in integration of the viral genome, with a preference for regions in the human genome containing active genes, viral expression, and production of new viruses. However, in rare cases T cells become latently infected, and this is presumed to be due to a combination of two factors: integrated viruses are not efficiently transcribed and infected T cells revert to a resting memory state. HIV latency has been associated with provirus integration in regions of constitutive heterochromatin, gene deserts, or very highly expressed genes. We have investigated the transcriptional consequences of latent HIV integration into cellular genes and the involvement o

SUBMITTER: Gallastegui E 

PROVIDER: S-EPMC3067836 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature