Atomic structures suggest determinants of transmission barriers in mammalian prion disease.

ABSTRACT: Prion represents a unique class of pathogens devoid of nucleic acid. The deadly diseases transmitted by it between members of one species and, in certain instances, to members of other species present a public health concern. Transmissibility and the barriers to transmission between species have been suggested to arise from the degree to which a pathological protein conformation from an individual of one species can seed a pathological conformation in another species. However, this hypothesis has never been illustrated at an atomic level. Here we present three X-ray atomic structures of the same segment from human, mouse, and hamster PrP, which is critical for forming amyloid and confers species specificity in PrP seeding experiments. The structures reveal that different sequences encode d

SUBMITTER: Apostol MI 

PROVIDER: S-EPMC3068218 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature