Lack of replication in polymorphisms reported to be associated with atrial fibrillation.

ABSTRACT:

Background

Atrial fibrillation (AF) is the most common sustained arrhythmia and has a substantial heritable component. Numerous associations between single nucleotide polymorphisms (SNPs) and AF have been described, but few have been replicated.

Objective

We sought to systematically replicate SNPs that are reported to be associated with AF in two large study samples of European descent.

Methods

We searched PubMed for studies reporting associations between SNPs and AF published before July 1, 2007. SNPs were genotyped in two independent case-control samples from Germany and the United States. Associations between SNPs and AF were assessed using logistic regression models adjusting for age, sex, and hypertension. A meta-analysis of the results from the two studies was p

SUBMITTER: Sinner MF 

PROVIDER: S-EPMC3068750 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature