Reconciliation of genome-scale metabolic reconstructions for comparative systems analysis.

ABSTRACT: In the past decade, over 50 genome-scale metabolic reconstructions have been built for a variety of single- and multi- cellular organisms. These reconstructions have enabled a host of computational methods to be leveraged for systems-analysis of metabolism, leading to greater understanding of observed phenotypes. These methods have been sparsely applied to comparisons between multiple organisms, however, due mainly to the existence of differences between reconstructions that are inherited from the respective reconstruction processes of the organisms to be compared. To circumvent this obstacle, we developed a novel process, termed metabolic network reconciliation, whereby non-biological differences are removed from genome-scale reconstructions while keeping the reconstructions as true as po

SUBMITTER: Oberhardt MA 

PROVIDER: S-EPMC3068926 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature