Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain.

ABSTRACT: Reactive oxygen species (ROS) produced in the mitochondrial respiratory chain (RC) are primary signals that modulate cellular adaptation to environment, and are also destructive factors that damage cells under the conditions of hypoxia/reoxygenation relevant for various systemic diseases or transplantation. The important role of ROS in cell survival requires detailed investigation of mechanism and determinants of ROS production. To perform such an investigation we extended our rule-based model of complex III in order to account for electron transport in the whole RC coupled to proton translocation, transmembrane electrochemical potential generation, TCA cycle reactions, and substrate transport to mitochondria. It fits respiratory electron fluxes measured in rat brain mitochondria fueled by

SUBMITTER: Selivanov VA 

PROVIDER: S-EPMC3068929 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature