Assignment of PolyProline II conformation and analysis of sequence--structure relationship.

ABSTRACT:

Background

Secondary structures are elements of great importance in structural biology, biochemistry and bioinformatics. They are broadly composed of two repetitive structures namely α-helices and β-sheets, apart from turns, and the rest is associated to coil. These repetitive secondary structures have specific and conserved biophysical and geometric properties. PolyProline II (PPII) helix is yet another interesting repetitive structure which is less frequent and not usually associated with stabilizing interactions. Recent studies have shown that PPII frequency is higher than expected, and they could have an important role in protein-protein interactions.

Methodology/principal findings

A major factor that limits the study of PPII is that its assignment cannot be carried out

SUBMITTER: Mansiaux Y 

PROVIDER: S-EPMC3069088 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature