Electrochemical measurement of endogenous serotonin release from human blood platelets.

ABSTRACT: Platelet aggregation in the bloodstream is tightly associated with the secretory function of platelets based on several types of cytoplasmic secretory granules, each sequestering distinct chemical messenger species. Dense-body granules are one prominent type of secretory granule responsible for storing small molecule chemical messengers. Upon platelet activation, the timely and rapid release of these small molecules is critical in facilitating platelet aggregation. Therefore, techniques capable of measuring real-time granule content release are needed to understand the fundamental properties of platelet secretion and aggregation. Existing techniques lack adequate time resolution or require potentially toxic exogenous reagents for real-time measurement of granule content release. Herein, we

SUBMITTER: Ge S 

PROVIDER: S-EPMC3069134 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature