Ontology highlight
ABSTRACT:
SUBMITTER: Hu R
PROVIDER: S-EPMC3069436 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Hu Rong R Liu Wei W Li Hui H Yang Li L Chen Chao C Xia Zhu-Ying ZY Guo Li-Juan LJ Xie Hui H Zhou Hou-De HD Wu Xian-Ping XP Luo Xiang-Hang XH
The Journal of biological chemistry 20110215 14
Our recent study showed that miR-2861 promotes osteoblast differentiation by targeting histone deacetylase 5, resulting in increased runt-related transcription factor 2 (Runx2) protein production. Here we identified another new microRNA (miRNA) (miR-3960) that played a regulatory role in osteoblast differentiation through a regulatory feedback loop with miR-2861. miR-3960 and miR-2861 were found clustered at the same loci. miR-3960 was transcribed during bone morphogenic protein 2 (BMP2)-induced ...[more]