On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase.

ABSTRACT: Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previously proposed for HEPD must be re-evaluated.

SUBMITTER: Whitteck JT 

PROVIDER: S-EPMC3069692 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature