Quercetin induces tumor-selective apoptosis through downregulation of Mcl-1 and activation of Bax.

ABSTRACT:

Purpose

To investigate the in vivo antitumor efficacy of quercetin in U937 xenografts and the functional roles of Mcl-1 and Bax in quercetin-induced apoptosis in human leukemia.

Experimental design

Leukemia cells were treated with quercetin, after which apoptosis, Mcl-1 expression, and Bax activation and translocation were evaluated. The efficacy of quercetin as well as Mcl-1 expression and Bax activation were investigated in xenografts of U937 cells.

Results

Administration of quercetin caused pronounced apoptosis in both transformed and primary leukemia cells but not in normal blood peripheral mononuclear cells. Quercetin-induced apoptosis was accompanied by Mcl-1 downregulation and Bax conformational change and mitochondrial translocation that triggered cytochrome c

SUBMITTER: Cheng S 

PROVIDER: S-EPMC3069720 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature