Competitive regulation of CaT-like-mediated Ca2+ entry by protein kinase C and calmodulin.

ABSTRACT: A finely tuned Ca(2+) signaling system is essential for cells to transduce extracellular stimuli, to regulate growth, and to differentiate. We have recently cloned CaT-like (CaT-L), a highly selective Ca(2+) channel closely related to the epithelial calcium channels (ECaC) and the calcium transport protein CaT1. CaT-L is expressed in selected exocrine tissues, and its expression also strikingly correlates with the malignancy of prostate cancer. The expression pattern and selective Ca(2+) permeation properties suggest an important function in Ca(2+) uptake and a role in tumor progression, but not much is known about the regulation of this subfamily of ion channels. We now demonstrate a biochemical and functional mechanism by which cells can control CaT-L activity. CaT-L is regulated by mean

SUBMITTER: Niemeyer BA 

PROVIDER: S-EPMC30699 | biostudies-literature | 2001 Mar

REPOSITORIES: biostudies-literature