Exoproteome of Staphylococcus aureus reveals putative determinants of nasal carriage.

ABSTRACT: Due to the increasing prevalence of nosocomial and community-acquired antibiotic resistant Staphylococcus aureus (SA), understanding the determinants of SA nasal carriage has become a major imperative. Previous research has revealed many host and bacterial factors that contribute to SA nasal carriage. To assess bacterial factors that facilitate nasal carriage, we compared the exoproteome of a nasal carrier strain of SA to a genetically similar noncarrier strain. Additionally, the carrier strain biofilm exoproteome was also compared against its planktonic counterpart. Using high throughput proteomics, it was observed that the carrier strain of SA secretes a greater number of proteins that may promote successful colonization of the human nose, including cell attachment and immunoevasive prot

SUBMITTER: Muthukrishnan G 

PROVIDER: S-EPMC3070068 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature