Peptide model helices in lipid membranes: insertion, positioning, and lipid response on aggregation studied by X-ray scattering.

ABSTRACT: Studying membrane active peptides or protein fragments within the lipid bilayer environment is particularly challenging in the case of synthetically modified, labeled, artificial, or recently discovered native structures. For such samples the localization and orientation of the molecular species or probe within the lipid bilayer environment is the focus of research prior to an evaluation of their dynamic or mechanistic behavior. X-ray scattering is a powerful method to study peptide/lipid interactions in the fluid, fully hydrated state of a lipid bilayer. For one, the lipid response can be revealed by observing membrane thickening and thinning as well as packing in the membrane plane; at the same time, the distinct positions of peptide moieties within lipid membranes can be elucidated at r

SUBMITTER: Schneggenburger PE 

PROVIDER: S-EPMC3070074 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature