Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner.

ABSTRACT:

Purpose

Parametric imaging of absolute myocardial blood flow (MBF) using [(15)O]H(2)O enables determination of MBF with high spatial resolution. The aim of this study was to develop a method for generating reproducible, high-quality and quantitative parametric MBF images with minimal user intervention.

Methods

Nineteen patients referred for evaluation of MBF underwent rest and adenosine stress [(15)O]H(2)O positron emission tomography (PET) scans. Ascending aorta and right ventricular (RV) cavity volumes of interest (VOIs) were used as input functions. Implementation of a basis function method (BFM) of the single-tissue model with an additional correction for RV spillover was used to generate parametric images. The average segmental MBF derived from parametric images was com

SUBMITTER: Harms HJ 

PROVIDER: S-EPMC3070081 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature