Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes.

ABSTRACT:

Objective

The objective of this study was to determine the role of maximum mitochondrial capacity on the variation in insulin sensitivity within a population of patients with type 2 diabetes mellitus (T2DM).

Research design and methods

Fifty-eight participants enrolled in a cross-sectional design: eight active controls [maximum aerobic capacity (VO(2max)) > 40 ml/kg · min], 17 healthy sedentary controls without a family history (FH-) and seven with a family history (FH+) of diabetes, four obese participants, and 21 patients with T2DM. Mitochondrial capacity was measured noninvasively using (31)P magnetic resonance spectroscopy of the vastus lateralis. Maximal ATP synthetic rate (ATP(max)) was determined from the rate of phosphocreatine (PCr) recovery after short-term isometr

SUBMITTER: Bajpeyi S 

PROVIDER: S-EPMC3070252 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature