Clinical evidence for predominance of delta-5 steroid production in women with polycystic ovary syndrome.

ABSTRACT:

Context

In women with polycystic ovary syndrome (PCOS), the basis for ovarian androgen overproduction involves an overall increase of steroidogenesis, notably in the delta-4 pathway. However, in vitro studies have suggested that excessive androgen production occurs predominantly through the delta-5 pathway.

Objective

This study was performed to assess androgen dose-responses after human chorionic gonadotropin (hCG) stimulation in PCOS and normal women.

Design

We conducted a prospective study to compare androgen production after iv hCG in PCOS and normal women.

Setting

The study was conducted in a General Clinical Research Center in an academic medical center.

Participants

Women with PCOS (age, 18-37 yr; n = 10) and normal ovulatory controls (age, 18-37 y

SUBMITTER: Rosencrantz MA 

PROVIDER: S-EPMC3070255 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature