Association between metabolic syndrome and liver histology among children with nonalcoholic Fatty liver disease.

ABSTRACT:

Objectives

Nonalcoholic steatohepatitis (NASH) is considered the hepatic manifestation of metabolic syndrome (MetS) among adults. Emerging data suggest that MetS may be associated with nonalcoholic fatty liver disease (NAFLD) in children as well. We sought to determine whether MetS or its component features are associated with specific histological features or severity of NAFLD.

Methods

Children and adolescents aged 6-17 years enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) with clinical data obtained within 6 months of liver biopsy were included. MetS was defined as the presence of three or more of the following features as determined by application of age-adjusted normative values: central obesity, dyslipidemia, impaired fasting glucose, a

SUBMITTER: Patton HM 

PROVIDER: S-EPMC3070291 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature