Oseltamivir-resistant influenza A and B viruses pre- and postantiviral therapy in children and young adults with cancer.

ABSTRACT:

Background

Immunocompromised patients are highly susceptible to influenza infection and can have prolonged viral shedding, which is a risk factor for the development of antiviral resistance.

Methods

We investigated the emergence of oseltamivir-resistant influenza variants in children and young adults with cancer during the 2002-2008 influenza seasons. The demographic and clinical features of influenza infections in 12 patients who had viral isolates obtained before and after oseltamivir therapy was initiated were studied. Antiviral susceptibilities were determined by the fluorescence-based neuraminidase (NA) enzyme inhibition assay and by sequencing genes encoding NA and matrix M2 proteins.

Results

The mean age of patients was 10.5 (range, 1.1-23.0) years. Ten patient

SUBMITTER: Carr S 

PROVIDER: S-EPMC3070406 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature