Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples.

ABSTRACT: Molecular targeted therapy represents a promising new strategy for treating cancers because many small-molecule inhibitors targeting protein kinases have recently become available. Reverse-phase protein microarrays (RPPAs) are a useful platform for identifying dysregulated signaling pathways in tumors and can provide insight into patient-specific differences. In the present study, RPPAs were used to examine 60 protein end points (predominantly phosphoproteins) in matched tumor and nonmalignant biopsy specimens from 23 patients with head and neck squamous cell carcinoma to characterize the cancer phosphoproteome. RPPA identified 18 of 60 analytes globally elevated in tumors versus healthy tissue and 17 of 60 analytes that were decreased. The most significantly elevated analytes in tumor wer

SUBMITTER: Frederick MJ 

PROVIDER: S-EPMC3070553 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature