Deregulation of E2-EPF ubiquitin carrier protein in papillary renal cell carcinoma.

ABSTRACT: Molecular pathways associated with pathogenesis of sporadic papillary renal cell carcinoma (PRCC), the second most common form of kidney cancer, are poorly understood. We analyzed primary tumor specimens from 35 PRCC patients treated by nephrectomy via gene expression analysis and tissue microarrays constructed from an additional 57 paraffin-embedded PRCC samples via immunohistochemistry. Gene products were validated and further studied by Western blot analyses using primary PRCC tumor samples and established renal cell carcinoma cell lines, and potential associations with pathologic variables and survival in 27 patients with follow-up information were determined. We show that the expression of E2-EPF ubiquitin carrier protein, which targets the principal negative regulator of hypoxia-indu

SUBMITTER: Roos FC 

PROVIDER: S-EPMC3070594 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature