Gene networks associated with conditional fear in mice identified using a systems genetics approach.

ABSTRACT:

Background

Our understanding of the genetic basis of learning and memory remains shrouded in mystery. To explore the genetic networks governing the biology of conditional fear, we used a systems genetics approach to analyze a hybrid mouse diversity panel (HMDP) with high mapping resolution.

Results

A total of 27 behavioral quantitative trait loci were mapped with a false discovery rate of 5%. By integrating fear phenotypes, transcript profiling data from hippocampus and striatum and also genotype information, two gene co-expression networks correlated with context-dependent immobility were identified. We prioritized the key markers and genes in these pathways using intramodular connectivity measures and structural equation modeling. Highly connected genes in the context fear

SUBMITTER: Park CC 

PROVIDER: S-EPMC3070648 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature