Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.

ABSTRACT: Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the human disease, and standardized validation criteria for psoriasis mouse models have not been widely applied. In this study, whole-genome transcriptional profiling is used to compare gene expression patterns manifested by human psoriatic skin lesions with those that occur in five psoriasis mouse models (K5-Tie2, imiquimod, K14-AREG, K5-Stat3C and K5-TGFbeta1). While the cutaneous gene expression profiles associated with each mouse phenotype exhibited statistically significant similarity to the expres

SUBMITTER: Swindell WR 

PROVIDER: S-EPMC3070727 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature