Association of toll-like receptor 5 gene polymorphism with susceptibility to ossification of the posterior longitudinal ligament of the spine in korean population.

ABSTRACT:

Objective

Ossification of the posterior longitudinal ligament (OPLL) has a strong genetic component. Specific gene polymorphisms may be associated with OPLL in several genes which regulate calcification in chondrocytes, change of extracellular collagen matrix and secretions of many growth factors and cytokines controlling bone morphogenesis. Toll-like receptor 5 (TLR5) may play a role in the pathogenesis of OPLL by intermediate nuclear factor-kappa B (NF-κB). The current study focused on coding single nucleotide polymorphisms (SNPs) of TLR5 for a case-control study investigating the relationship between TLR5 and OPLL in a Korean population.

Methods

A total of 166 patients with OPLL and 231 controls were recruited for a case-control association study investigating the relatio

SUBMITTER: Chung WS 

PROVIDER: S-EPMC3070903 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature