Early CPAP versus surfactant in extremely preterm infants.

ABSTRACT:

Background

There are limited data to inform the choice between early treatment with continuous positive airway pressure (CPAP) and early surfactant treatment as the initial support for extremely-low-birth-weight infants.

Methods

We performed a randomized, multicenter trial, with a 2-by-2 factorial design, involving infants who were born between 24 weeks 0 days and 27 weeks 6 days of gestation. Infants were randomly assigned to intubation and surfactant treatment (within 1 hour after birth) or to CPAP treatment initiated in the delivery room, with subsequent use of a protocol-driven limited ventilation strategy. Infants were also randomly assigned to one of two target ranges of oxygen saturation. The primary outcome was death or bronchopulmonary dysplasia as defined by the re

SUBMITTER: SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network 

PROVIDER: S-EPMC3071534 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature