Ontology highlight
ABSTRACT:
SUBMITTER: Lammens K
PROVIDER: S-EPMC3071652 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Cell 20110401 1
The MR (Mre11 nuclease and Rad50 ABC ATPase) complex is an evolutionarily conserved sensor for DNA double-strand breaks, highly genotoxic lesions linked to cancer development. MR can recognize and process DNA ends even if they are blocked and misfolded. To reveal its mechanism, we determined the crystal structure of the catalytic head of Thermotoga maritima MR and analyzed ATP-dependent conformational changes. MR adopts an open form with a central Mre11 nuclease dimer and two peripheral Rad50 mo ...[more]