Spotlight on differentially expressed genes in urinary bladder cancer.

ABSTRACT:

Introduction

We previously identified common differentially expressed (DE) genes in bladder cancer (BC). In the present study we analyzed in depth, the expression of several groups of these DE genes.

Materials and methods

Samples from 30 human BCs and their adjacent normal tissues were analyzed by whole genome cDNA microarrays, qRT-PCR and Western blotting. Our attention was focused on cell-cycle control and DNA damage repair genes, genes related to apoptosis, signal transduction, angiogenesis, as well as cellular proliferation, invasion and metastasis. Four publicly available GEO Datasets were further analyzed, and the expression data of the genes of interest (GOIs) were compared to those of the present study. The relationship among the GOI was also investigated. GO and KEG

SUBMITTER: Zaravinos A 

PROVIDER: S-EPMC3071699 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature