Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults. Despite concerted efforts to improve current therapies and develop novel clinical approaches, patient survival remains poor. As such, increasing attention has focused on developing new therapeutic strategies that specifically target the apoptotic pathway in order to improve treatment responses. Recently, nutlins, small-molecule antagonists of MDM2, have been developed to inhibit p53-MDM2 interaction and activate p53 signaling in cancer cells. Glioma cell lines and primary cultured glioblastoma cells were treated with nutlin-3a. Nutlin-3a induced p53-dependent G1- and G2-M cell cycle arrest and apoptosis in glioma cell lines with normal TP53 status. In addition, nutlin-arrested glioma cells show m

SUBMITTER: Villalonga-Planells R 

PROVIDER: S-EPMC3071734 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature