Patients with MCI and N400 or P600 abnormalities are at very high risk for conversion to dementia.

ABSTRACT:

Objective

We sought cognitive event-related potential (ERP) biomarkers of disease progression and subsequent conversion to dementia in mild cognitive impairment (MCI).

Background

Two ERP components, the P600 and N400, are sensitive to abnormal episodic/declarative memory and semantic processing. When congruous category-exemplars are repeated, smaller P600s (relative to initial presentation) are normally elicited. Repetitions of semantically incongruous words yield smaller N400 amplitude. In mild Alzheimer disease (AD), abnormalities of both the N400 and P600 repetition effects are present, suggesting a widespread failure of synaptic plasticity.

Methods

Patients with amnestic MCI (n = 32) were longitudinally studied annually with an ERP paradigm in which semantically c

SUBMITTER: Olichney JM 

PROVIDER: S-EPMC3071795 | biostudies-literature | 2008 May

REPOSITORIES: biostudies-literature