The heritability of beta cell function parameters in a mixed meal test design.

ABSTRACT:

Aims/hypothesis

We estimated the heritability of individual differences in beta cell function after a mixed meal test designed to assess a wide range of classical and model-derived beta cell function parameters.

Methods

A total of 183 healthy participants (77 men), recruited from the Netherlands Twin Register, took part in a 4 h protocol, which included a mixed meal test. Participants were Dutch twin pairs and their siblings, aged 20 to 49 years. All members within a family were of the same sex. Insulin sensitivity, insulinogenic index, insulin response and postprandial glycaemia were assessed, as well as model-derived parameters of beta cell function, in particular beta cell glucose sensitivity and insulin secretion rates. Genetic modelling provided the heritability of all

SUBMITTER: Simonis-Bik AM 

PROVIDER: S-EPMC3071945 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature