Reduced stability of mRNA secondary structure near the translation-initiation site in dsDNA viruses.

ABSTRACT:

Background

Recent studies have demonstrated a selection pressure for reduced mRNA secondary-structure stability near the start codon of coding sequences. This selection pressure can be observed in bacteria, archaea, and eukaryotes, and is likely caused by the requirement of efficient translation initiation in cellular organism.

Results

Here, we surveyed the complete genomes of 650 dsDNA virus strains for signals of reduced stability of mRNA secondary structure near the start codon. Our analysis included viruses infecting eukaryotic, prokaryotic, and archaeic hosts. We found that many viruses showed evidence for reduced mRNA secondary-structure stability near the start codon. The effect was most pronounced in viruses infecting prokaryotes, but was also observed in viruses inf

SUBMITTER: Zhou T 

PROVIDER: S-EPMC3072339 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature