Nuclear envelope structural defects cause chromosomal numerical instability and aneuploidy in ovarian cancer.

ABSTRACT:

Background

Despite our substantial understanding of molecular mechanisms and gene mutations involved in cancer, the technical approaches for diagnosis and prognosis of cancer are limited. In routine clinical diagnosis of cancer, the procedure is very basic: nuclear morphology is used as a common assessment of the degree of malignancy, and hence acts as a prognostic and predictive indicator of the disease. Furthermore, though the atypical nuclear morphology of cancer cells is believed to be a consequence of oncogenic signaling, the molecular basis remains unclear. Another common characteristic of human cancer is aneuploidy, but the causes and its role in carcinogenesis are not well established.

Methods

We investigated the expression of the nuclear envelope proteins lamin A/C

SUBMITTER: Capo-chichi CD 

PROVIDER: S-EPMC3072346 | biostudies-literature | 2011 Mar

REPOSITORIES: biostudies-literature