Modification of gene duplicability during the evolution of protein interaction network.

ABSTRACT: Duplications of genes encoding highly connected and essential proteins are selected against in several species but not in human, where duplicated genes encode highly connected proteins. To understand when and how gene duplicability changed in evolution, we compare gene and network properties in four species (Escherichia coli, yeast, fly, and human) that are representative of the increase in evolutionary complexity, defined as progressive growth in the number of genes, cells, and cell types. We find that the origin and conservation of a gene significantly correlates with the properties of the encoded protein in the protein-protein interaction network. All four species preserve a core of singleton and central hubs that originated early in evolution, are highly conserved, and accomplish basic

SUBMITTER: D'Antonio M 

PROVIDER: S-EPMC3072358 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature