Evidence for an association between migraine and the hypocretin receptor 1 gene.
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ABSTRACT:
SUBMITTER: Rainero I
PROVIDER: S-EPMC3072499 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
Evidence for an association between migraine and the hypocretin receptor 1 gene.
Rainero Innocenzo I Rubino Elisa E Gallone Salvatore S Fenoglio Pierpaola P Picci Luigi Rocco LR Giobbe Laura L Ostacoli Luca L Pinessi Lorenzo L
The journal of headache and pain 20110223 2
The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case-control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ(2)=9.872, p=0.007; χ(2)=8.108, p=0.004) between migraineurs and controls. The carriage of the A allele was ...[more]
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