Modafinil modulation of the default mode network.

ABSTRACT:

Rationale

The default mode network (DMN) is a functional network which is implicated in a range of cognitive processes. This network is proposed to consist of hubs located in the ventromedial prefrontal cortex (vmPFC), posterior cingulate/retrosplenial cortex (PCC/rSpl), and inferior parietal lobule (IPL), with other midline cortical and temporal lobe nodes connected to these hubs. How this network is modulated by neurochemical systems during functional brain activity is not yet understood.

Objectives

In the present study, we used the norepinephrine/dopamine transporter inhibitor modafinil to test the hypothesis that this drug modulates the DMN.

Methods

Eighteen healthy right-handed adults participated in a double-blind, placebo-controlled study of single oral dose mo

SUBMITTER: Minzenberg MJ 

PROVIDER: S-EPMC3072511 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature