Association between familial atrial fibrillation and risk of new-onset atrial fibrillation.

ABSTRACT:

Context

Although the heritability of atrial fibrillation (AF) is established, the contribution of familial AF to predicting new-onset AF remains unknown.

Objective

To determine whether familial occurrence of AF is associated with new-onset AF beyond established risk factors.

Design, setting, and participants

The Framingham Heart Study, a prospective community-based cohort study started in 1948. Original and Offspring Cohort participants were aged at least 30 years, were free of AF at the baseline examination, and had at least 1 parent or sibling enrolled in the study. The 4421 participants in this analysis (mean age, 54 [SD, 13] years; 54% women) were followed up through December 31, 2007.

Main outcome measures

Incremental predictive value of incorporating diff

SUBMITTER: Lubitz SA 

PROVIDER: S-EPMC3073054 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature