Trends in estradiol during critical illness are associated with mortality independent of admission estradiol.

ABSTRACT:

Background

We have previously demonstrated that elevated serum estradiol (E(2)) at intensive care unit (ICU) admission is associated with death in the critically ill, regardless of sex. However, little is known about how changes in initial E(2) during the course of care might signal increasing patient acuity or risk of death. We hypothesized that changes from baseline serum E(2) during the course of critical illness are more strongly associated with mortality than a single E(2) level at admission.

Study design

A prospective cohort of 1,408 critically ill or injured nonpregnant adult patients requiring ICU care for ≥48 hours with admission and subsequent E(2) levels was studied. Demographics, illness severity, and E(2) levels were examined, and the probability of mortality wa

SUBMITTER: Kauffmann RM 

PROVIDER: S-EPMC3073628 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature