Gene-air pollution interaction and cardiovascular disease: a review.

ABSTRACT: Genetic susceptibility is likely to play a role in response to air pollution. Hence, gene-environment interaction studies can be a tool for exploring the mechanisms and the importance of the pathway in the association between air pollution and a cardiovascular outcome. In this article, we present a systematic review of the studies that have examined gene-environment interactions in relation to the cardiovascular health effects of air pollutants. We identified 16 articles meeting our search criteria. Of these studies, most have focused on individual functional polymorphisms or individual candidate genes. Moreover, they were all based on 3 study populations that have been extensively investigated in relation to air pollution effects: the Normative Aging Study, Air Pollution and Inflammatory

SUBMITTER: Zanobetti A 

PROVIDER: S-EPMC3073822 | biostudies-literature | 2011 Mar-Apr

REPOSITORIES: biostudies-literature