Associations of CYP2A6 genotype with smoking behaviors in southern China.

ABSTRACT:

Aims

To investigate the association of CYP2A6 genetic polymorphisms with smoking-related phenotypes in Chinese smokers.

Design

Case-only genetic association study.

Setting

Southern China.

Participants

A total of 1328 Han Chinese smokers who participated in a community-based chronic disease screening project in Guangzhou and Zhuhai from 2006 to 2007.

Measurements

All participants answered a structured questionnaire about socio-demographic status and smoking behaviors and informative alleles were genotyped for the cytochrome P450 2A6 (CYP2A6) gene (CYP2A6*4,*5,*7,*9 and *10).

Findings

The frequencies of CYP2A6*4, *5, *7, *9 and *10 alleles were 8.5, 1.2, 6.3, 13.5 and 2.4%, which corresponded to 48.9, 15.4, 24.2 and 11.5% of participants being class

SUBMITTER: Liu T 

PROVIDER: S-EPMC3074015 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature