Regulatory modules function in a non-autonomous manner to control transcription of the mbp gene.

ABSTRACT: Multiple regulatory modules contribute to the complex expression programs realized by many loci. Although long thought of as isolated components, recent studies demonstrate that such regulatory sequences can physically associate with promoters and with each other and may localize to specific sub-nuclear transcription factories. These associations provide a substrate for putative interactions and have led to the suggested existence of a transcriptional interactome. Here, using a controlled strategy of transgenesis, we analyzed the functional consequences of regulatory sequence interaction within the myelin basic protein (mbp) locus. Interactions were revealed through comparisons of the qualitative and quantitative expression programs conferred by an allelic series of 11 different enhancer/i

SUBMITTER: Dib S 

PROVIDER: S-EPMC3074125 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature