Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon.

ABSTRACT: Because iron toxicity and deficiency are equally life threatening, maintaining intracellular iron levels within a narrow optimal range is critical for nearly all known organisms. However, regulatory mechanisms that establish homeostasis are not well understood in organisms that dwell in environments at the extremes of pH, temperature, and salinity. Under conditions of limited iron, the extremophile Halobacterium salinarum, a salt-loving archaeon, mounts a specific response to scavenge iron for growth. We have identified and characterized the role of two transcription factors (TFs), Idr1 and Idr2, in regulating this important response. An integrated systems analysis of TF knockout gene expression profiles and genome-wide binding locations in the presence and absence of iron has revealed tha

SUBMITTER: Schmid AK 

PROVIDER: S-EPMC3074139 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature