COMODO: an adaptive coclustering strategy to identify conserved coexpression modules between organisms.

ABSTRACT: Increasingly large-scale expression compendia for different species are becoming available. By exploiting the modularity of the coexpression network, these compendia can be used to identify biological processes for which the expression behavior is conserved over different species. However, comparing module networks across species is not trivial. The definition of a biologically meaningful module is not a fixed one and changing the distance threshold that defines the degree of coexpression gives rise to different modules. As a result when comparing modules across species, many different partially overlapping conserved module pairs across species exist and deciding which pair is most relevant is hard. Therefore, we developed a method referred to as conserved modules across organisms (COMODO)

SUBMITTER: Zarrineh P 

PROVIDER: S-EPMC3074154 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature