The microRNA pathway regulates the temporal pattern of Notch signaling in Drosophila follicle cells.

ABSTRACT: Multicellular development requires the correct spatial and temporal regulation of cell division and differentiation. These processes are frequently coordinated by the activities of various signaling pathways such as Notch signaling. From a screen for modifiers of Notch signaling in Drosophila we have identified the RNA helicase Belle, a recently described component of the RNA interference pathway, as an important regulator of the timing of Notch activity in follicle cells. We found that loss of Belle delays activation of Notch signaling, which results in delayed follicle cell differentiation and defects in the cell cycle. Because mutations in well-characterized microRNA components phenocopied the Notch defects observed in belle mutants, Belle might be functioning in the microRNA pathway in

SUBMITTER: Poulton JS 

PROVIDER: S-EPMC3074450 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature