Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-γ response.

ABSTRACT:

Background

The basis for increased susceptibility of patients with atopic dermatitis (AD) to develop disseminated viral skin infections such as eczema herpeticum (AD with a history of eczema herpeticum, ADEH(+)) is poorly understood.

Objective

We sought to determine whether subjects with AD prone to disseminated viral skin infections have defects in their IFN responses.

Methods

GeneChip profiling was used to identify differences in gene expression of PBMCs from patients with ADEH(+) compared with patients with AD without a history of eczema herpeticum (ADEH(-)) and nonatopic controls. Key differences in protein expression were verified by enzyme-linked immunosorbent spot assay and/or ELISA. Clinical relevance was further demonstrated by a mouse model of disseminated v

SUBMITTER: Leung DY 

PROVIDER: S-EPMC3074534 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature