Asymmetric synthesis of enantiopure isoxazolidinone monomers for the synthesis of β-oligopeptides by chemoselective amide ligation.

ABSTRACT: The design and general synthesis of enantiopure isoxazolidinone monomers as precursors for the preparation of enantiopure N-terminal hydroxylamine-β(3)-oligopeptides, which may be used as reaction partners with α-ketoacids in the decarboxylative amide ligation reaction, is described.

SUBMITTER: Juarez-Garcia ME 

PROVIDER: S-EPMC3074535 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature