Estrogen receptor polymorphisms and the vascular effects of hormone therapy.

ABSTRACT:

Objective

To test whether estrogen receptor polymorphisms modify the effects of postmenopausal hormone therapy on biomarkers and on risk of coronary heart disease events, stroke, or venous thromboembolism.

Methods and results

The design was a nested case-control study in the Women's Health Initiative trials of postmenopausal hormone therapy. The study included all cases in the first 4 years: 359 cases of coronary heart disease, 248 of stroke, and 217 of venous thromboembolism. Six estrogen receptor-α polymorphisms and 1 estrogen receptor-β polymorphism were genotyped; 8 biomarkers known to be affected by hormone therapy were measured at baseline and 1 year after randomization. The polymorphisms were not associated with risk of vascular events and did not modify the increased

SUBMITTER: Rossouw J 

PROVIDER: S-EPMC3074605 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature