In Silico Design of Novel Anticoagulant Peptides targeting Blood Coagulation Factor VIIa.

ABSTRACT:

Objectives

The coagulation cascade initiated during vascular injury prevents bleeding. Unwanted clot formation is however detrimental and requires the use of anticoagulants for prophylaxis and treatment. Anticoagulants targeting a specific step or an enzyme in the clotting process are most preferred as they minimise disadvantageous side-effects. A principal step in the discovery of novel anticoagulants encompasses the in silico design of potential leads. This study depicts the in silico design of peptide anticoagulants targeting coagulation factor VIIa.

Methods

APPLYING THE PROLINE BRACKET RULE AND USING VARIOUS BIOINFORMATICS TOOLS: the basic alignment search tool (BLAST) of National Center for Biotechnology Information; the T-coffee module provided by European Molecular Bi

SUBMITTER: Al-Amri MS 

PROVIDER: S-EPMC3074690 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature