Ventricular diastolic dysfunction in sickle cell anemia is common but not associated with myocardial iron deposition.

ABSTRACT:

Background

Cardiac failure from myocardial iron deposition is a severe complication in patients with transfusion-related iron overload. Progressive heart damage from iron overload can cause left ventricular systolic and diastolic dysfunction in patients with hematologic disorders. Since nontransfused patients with sickle cell anemia (SCA) have a high incidence of diastolic dysfunction, we investigated the relationships among transfusional iron burden, myocardial iron deposition, and diastolic ventricular dysfunction by T2*-MRI and tissue Doppler echocardiography in iron-overloaded children with SCA.

Procedure

Children (> or =7 years) with SCA and iron overload (serum ferritin >1,000 ng/ml or > or =18 lifetime transfusions) were eligible. Serum ferritin and hepatic iron conte

SUBMITTER: Hankins JS 

PROVIDER: S-EPMC3075427 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature