Serum biomarker panels for the detection of pancreatic cancer.

ABSTRACT:

Purpose

Serum-biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations.

Experimental design

Eighty-three circulating proteins were analyzed in sera of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC, n = 333), benign pancreatic conditions (n = 144), and healthy control individuals (n = 227). Samples from each group were split randomly into training and blinded validation sets prior to analysis. A Metropolis algorithm with Monte Carlo simulation (MMC) was used to identify discriminatory biomarker panels in the training set. Identified panels were evaluated in the validation set and in patients diagnosed with colon (n = 33), lung (n = 62), and breast (n = 108) cancers.

Results

Several r

SUBMITTER: Brand RE 

PROVIDER: S-EPMC3075824 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature