A stereoselective synthesis of (+)-herboxidiene/GEX1A.

ABSTRACT: A stereoselective synthesis of (+)-herboxidiene is described. The convergent synthesis utilized a Suzuki cross-coupling reaction to assemble the key segments. The synthesis of the functionalized tetrahydropyran ring utilized an Achmatowicz reaction as the key step. The synthesis of the C10-C19 segment was accomplished using Brown's crotylboration, asymmetric alkylation, and a stereoselective allylic chlorination reactions.

SUBMITTER: Ghosh AK 

PROVIDER: S-EPMC3075843 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature