In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques.

ABSTRACT:

Background

Single-walled carbon nanotubes (SWCNT) hold promise for applications as contrast agents and target delivery carriers in the field of nanomedicine. When administered in vivo, their biodistribution and pharmacological profile needs to be fully characterized. The tissue distribution of carbon nanotubes and their potential impact on metabolism depend on their shape, coating, and metallic impurities. Because standard radiolabeled or fluorescently-labeled pharmaceuticals are not well suited for long-term in vivo follow-up of carbon nanotubes, alternative methods are required.

Methods

In this study, noninvasive in vivo magnetic resonance imaging (MRI) investigations combined with high-resolution magic angle spinning (HR-MAS), Raman spectroscopy, iron assays, and histolog

SUBMITTER: Al Faraj A 

PROVIDER: S-EPMC3075901 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature